Executive Order 14355 explained · Executive Order · No disposition noted
Unlocking Cures for Pediatric Cancer With Artificial Intelligence
Signed: 2025-09-30 Published: 2025-10-07 Federal Register document: 2025-19495
Agencies: Executive Office of the President
Federal Register notes (as of 2026-10-19): See: EO 14212, February 13, 2025
What Executive Order 14355 says
Federal Register, Volume 90 Issue 192 (Tuesday, October 7, 2025) [Federal Register Volume 90, Number 192 (Tuesday, October 7, 2025)] [Presidential Documents] [Pages 48153-48155] From the Federal Register Online via the Government Publishing Office [www.gpo.gov] [FR Doc No: 2025-19495] [[Page 48151]] Vol. 90 Tuesday, No. 192 October 7, 2025 Part II The President ----------------------------------------------------------------------- Executive Order 14355--Unlocking Cures for Pediatric Cancer With Artificial Intelligence Presidential Documents Federal Register / Vol. 90 , No. 192 / Tuesday, October 7, 2025 / Presidential Documents ___________________________________________________________________ Title 3-- The President [[Page 48153]] Executive Order 14355 of September 30, 2025 Unlocking Cures for Pediatric Cancer With Artificial Intelligence By the authority vested in me as President by the Constitution and the laws of the United States of America, it is hereby ordered: Section 1. Purpose and Policy. My Administration is committed to driving innovation to prevent and treat childhood diseases, including through the use of artificial intelligence (AI). Pediatric cancer remains the leading cause of disease-related death for children in the United States aged 1-19 years, and its incidence has increased by more than 40 percent since 1975. As outlined in my joint address to the...
Opening of the official text; read it in full in the Federal Register.
Constitution Index
“VFA Constitution grade”
Constitutionally sound
Graded 2026-10-08
SI-generated grade · five published checks · not individually reviewed by a person · methodology
Executive Order 14355 directs existing federal health and science officials to coordinate, prioritize existing funds, improve interoperability with privacy and patient control, and encourage voluntary private research to improve pediatric cancer diagnostics and treatment using advanced artificial intelligence methods. It creates no mandate, no seizure of data, no new spending, and no preemption of states, operating within presidential supervision of the executive branch and congressional health-research authority.
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✓ Passes · Enumerated powers
As an executive direction to existing departments, this falls under Article II, Section 1 vesting of executive power and Article II, Section 3 duty to take care that the laws be faithfully executed, directing the Secretary of Health and Human Services, Office of Management and Budget, National Institutes of Health, and science advisors within statutes creating those agencies. Underlying spending d… -
✓ Passes · Bill of Rights
No provision restricts speech, religion, press, assembly, or petition under the First Amendment; no disarmament under the Second Amendment; no quartering, search, seizure, compelled testimony, or unfair trial procedure. Section 1 and Section 4 expressly require appropriate individual privacy protections, patient and parental control of health information, and safe and privacy-compliant exchange of… -
✓ Passes · Individual sovereignty
The order imposes no mandate, prohibition, or penalty on personal medical choice, speech, belief, labor, or property use. Participation in data sharing and clinical trials is framed as voluntary, privacy-protected, and patient-controlled under Section 4, with the government burden of protecting confidentiality acknowledged. Encouragement of private sector use of advanced technologies under Section… -
✓ Passes · Decentralization
Pediatric cancer multimodal data aggregation, multi-omics analysis, and nationwide clinical trial matching at National Cancer Institute-Designated Cancer Centers cannot practically be performed by an individual family, county, or single state alone because the patient population is small, dispersed across states, and requires interoperable federal datasets already held under the Childhood Cancer D… -
✓ Passes · Due process and takings
No person is deprived of life, liberty, or property without notice and hearing under the Fifth Amendment Due Process Clause, no criminal presumption is altered under the Fifth and Sixth Amendments, and no property is taken for public use without just compensation under the Fifth Amendment Takings Clause. Data use is conditioned on privacy-compliant, patient-controlled sharing and interoperability …
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